Some of the missense mutations of BDNF have been theoretically implicated (rs6265 in particular) to influence various outcomes of brain injury. Can someone please elaborate on how certain genetic polymorphisms of BDNF may aggravate cerebral oedema in mild TBI. If you have come across any such articles, please feel free to share.
May be you can read Dr Yu Hasegawa's article from Stroke. May be not clear explanation for you but it can give you way.
Thank you for your kind suggestions, Dr Altay. Will surely check the paper out.
I am currently working on how certain genetic predispositions actually affects the events that occurs in between the primary insult and the secondary trauma in brain injury. For example, rs6265 of BDNF has been implicated to negatively affect certain psychiatric conditions. However, not much work has been done in mTBI, especially with regards to its influence on microstructural changes across different time intervals. While working on the DTI results, we realised that some quarter of our patients with vasogenic edema and astrogliosis (evinced in the preliminary results) performing poorly in neurocognitive assessments across the time points in comparison to others from the same mTBI group. We would like to understand why..
(I posted the question in order to encourage people to share their opinions and engage one another in the effort of advancing the limited knowledge on the subject matter.)
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