When you are investigating a particular NHR signaling pathway for the worm development, how do you know whether it has therapeutic potential or not? Is the treatment likely toxic or not? Can you utilize comparative genomics to have an initial assessment?
Michal Okoniewski
I would try something around this way: Check if the worm pathway has homologous one in human - by checking in Kegg/David etc or by gene homologs (Ensembl). Find the key genes, and do the human cell lines experiments (eg. knockout) to prove your hypotheses of therapeutic potential - here you can use comparative genomics, eg RNAseq.
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