There are many publications using fluoxetine as a standard treatment in corticosterone induced depression and in these publications it is shown that fluoxetine lowers serum corticosterone levels. Through which mechanism fluoxetine lowers serum corticosterone concentration.
I think it is no possible. Yuou must stop the corticotherapy ! (gradually)
thank you sir..... but there are publications using fluoxetine as standard drug in corticosterone induced depression in animal models and where it lowered serum cort levels
Hope these two articles help!
http://www.ncbi.nlm.nih.gov/pubmed/?term=willner+2013+antidepressant
http://www.ncbi.nlm.nih.gov/pubmed/8852529
SSRIs are not the best in reducing hyperactivity of the HPA axis. I think that tricyclics such as amitriptyline, doxepin, tianeptine, or mirtazapine / mianserin do it effectively. Agonism of 5-HT1a, 5-HT 2A / c increases the activity of the HPA axis, so SSRIs may not work. I think that antagonists of 5-HT2a/c and H1 are more effective in this.
https://www.researchgate.net/publication/51170272_A_placebo-controlled_study_of_sertraline%27s_effect_on_cortisol_response_to_the_dexamethasonecorticotropin-releasing_hormone_test_in_healthy_adults
Article A placebo-controlled study of sertraline's effect on cortiso...
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