I want to assess the effect of quercetin on wound healing, so I want know the dose of quercetin for topical application. Is there any literature of dose of quercetin for topical application or wound healing? If no, what would be the approach for selecting the dose? if I go for pilot trial, then what would be the range of doses of quercetin? Should I use the log doses for selecting the dose range? If yes, then what can be the suitable log doses?
it totally depends upon what kind of formulation you will prepare and also in which model you are going to use it (Excission, Incision, Burn Model), also please consider the repithelisation and cell proliferation process by your drug, because the high concentration may damages the skin, and in open wound drug can easily passes the skin layer and increases the chances of drug adverse effect.
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