Because of other things -It may be because men have more contact with society, whether through work, meeting his friends, etc. .....

حنان عطية

Thank you very much

We can see that men aren't as careful about physical distancing, this is obvious at supermarkets, right? Women also have stronger immune system, but in men, the cytokine reactions are excessive and often fatal. Men tend to socialize more, smoke and drink more than women, although no one is an angel. And unfortunately, men have higher concentration of ACE2, the protein that sars cov 2 binds upon.

Could be genetic or hormonal.

Moez Ltifi

Dear Professor,

The topic of discussion that you have raised sounds very interesting and thank you for that. But is there any proven evidence for this? Is it being observed in selected places or is it the world picture?

Best regards,

Anamitra.

Serdar Kalemci

Anamitra Roy

Azzawi Hadi

Amina Othmani

Serdar Kalemci

Thank you very much

In our country, men usually do all kinds of outdoor work. It may be one of the reason behind of it.

The reason is that men are more mixed and are less committed to prevention measures

This phenomenon (higher mortality from COVID-19 in men) is not yet fully understood. However, many factors can be involved. Some of them are: hormones, different immune responses in men and women, sex-related differences in the distribution/prevalence of major cardiovascular risk factors and comorbidities, ...

You may find these articles of interest:

Article Sex differences in severity and mortality from COVID-19: are...

Article Sex differences in immune responses that underlie COVID-19 d...

Article Higher mortality of COVID-19 in males: Sex differences in im...

Article Considering how biological sex impacts immune responses and ...

chromosome XY makes man weaker than woman. Take care yourselves, COVID-19 free, happy with your works and your research.

اسرار عبدالزهرة

Marius Baguma

Terri Purvis

Osamah K.Abdulretha Alsharifi

Prasart Nuangchalerm

Md. Abdur Razzak Choudhury

Thank you for your contribution

More COVID 19 specific studies and evidences for gender disparity are needed

Samuel Oluyomi Ayodele

Thank you for your contribution

You are highly welcome Sir Moez Ltifi

Please have a look at the following RG links.

Article Covid-19 Kills More Men Than Women: An Overview of Possible Reasons

Article What's Sex Got to Do With COVID-19? Gender-Based Differences...

As worker men are more than worker women

Terri Purvis

Muhammad Arshad

Arvind Singh

Thank you for your contribution

Agreed with your opinion. Death rate is higher in man than women.

Amjad Ali

Thank you for your contribution

Men travel a lot compared to women, hence are more exposed.

For my knowledge there is no a clear scientific reason yet.

The difference is, above all, in the social behavior of men and women. A woman is more careful about her health, she is more executive. This plays a big role. In principle, it is difficult to say whether female or male physiology is affected or not. But today men get sick more than women. Perhaps this is due to social behavior. There is also a scientific explanation.

There are studies that have confirmed the presence of ACE2 receptors (through which the virus enters the body) in the tissues of the male reproductive organs, in the tissues of the testicles.

Female sex hormones prevent infection.

Moez Ltifi

Women have stronger immune systems than men.

Thanks!

Dear Moez Ltifi thank you for this interesting and very important technical question. In fact, it seems now well-established that the death rate for men from COVID-19 is higher than for women. For more recent information about the possible reasons please see the following useful links:

1. Coronavirus (COVID-19) and the different effects on men and women in the UK, March 2020 to February 2021

https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19andthedifferenteffectsonmenandwomenintheukmarch2020tofebruary2021/2021-03-10

(published March 10, 2021)

2. Fewer COVID-19 cases among women in Africa: WHO analysis

https://reliefweb.int/report/world/fewer-covid-19-cases-among-women-africa-who-analysis

(published March 4, 2021)

3. More men dying with coronavirus than women - despite gap closing during summer, ONS

https://news.sky.com/story/more-men-dying-with-coronavirus-than-women-despite-gap-closing-during-summer-ons-12241682

(published March 10, 2021)

Omar H. Abdalla

Talal A. Zari

Thank you for your contribution.

Usually all men have higher exposure to the Covid 19, and do interactions with others higher then female. So it is understood that the death rat will also be high as compare to females.

Direct exposure to the virus, and we have the fact that women are much more careful, moreover even in the vital system it is the mother who protects everything!

Meriem Ait Mohammed Zaib Ullah

Thank you for your contribution.

Transcription of transmembrane protease serine 2 (TMPRSS2) is largely accused, alongside angiotensin-converting enzyme 2 (ACE2), of helping the coronavirus enter the target cells, and regulation of TMPRSS2 is mediated by androgen receptor.

This makes males more vulnerable to a stronger infection and more likely to die.

Article SARS-COV-2 infection is likely to be androgen mediated

Article Androgen Receptor-Activated Enhancers Simultaneously Regulat...

Article Androgen regulation of the TMPRSS2 gene and the effect of a ...

Men are typically less robust than women in terms of physical health.

Women bear the pain more than men.

Because of, men do the outdoor works comparatively more.

Females have higher numbers of CD4+ T cells, more robust CD8+ T cell cytotoxic activity, and increased B cell production of immunoglobulin compared to males.

https://www.nature.com/articles/s41467-020-19741-6

I believe it is attributable to societal variables, occupational exposures, and biological variances.

Hi. I think because they mix with others more and of less fear from Covid19.

It could be linked to some sex-based differences we're seeing in men and women in the context of COVID-19, such as sex chromosome-linked genes, sex hormones, and the microbiome, which all control aspects of immune responses to infection and are potentially important biological contributors to the sex-based differences we're seeing in men and women.

Probably men take more chances and gets exposed more comparatively.

Men have higher concentrations of angiotensin-converting enzyme 2 (ACE2) in their blood than women. SARS-CoV-2, the virus that causes COVID-19 uses ACE2 to gain cellular entry.

https://academic.oup.com/eurheartj/article/41/19/1810/5834647

https://academic.oup.com/eurheartj/article/41/19/1818/5834646

According to the following article, the causes are explained in terms of activity of the immune system and its modulation by sex hormones, coagulation pattern, and preexisting cardiovascular diseases as well as effects deriving from smoking and drinking habits. See the following useful RG link: Article Covid-19 Kills More Men Than Women: An Overview of Possible Reasons

Kindly see the useful RG link: Article Sex differences in the case-fatality rates for COVID-19—A co...

Other study explained the causes due to demographic factors or countries' health profiles. See the following useful link: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30464-2/fulltext

It may be due to that women have strong immune than men in addition that men have more contact with society than women.

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjt9o6skNX1AhXG8HMBHfMnCYcQFnoECCEQAQ&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6345642%2F&usg=AOvVaw0rGy2JPKI0S89VQLomyIe0 - To some extent mental strength of women is more rigid than men .

Men seem to have more comorbidities than women