"Socio-demographic factors" may in fact be genetic for two reasons. 1) Social status is largely transmitted within a family, and familial transmission is in part an environnemental sensu lato, in part genetic. 2) Geographical origin, particularly in Southern Italy, is noted as a "socio-demographic factor"; it may, in fact, act  through a genetic founder effect, and the origin in Calabria of the largest documented Alzheimer kindred not be a coincidence (BRUNI A.C, MONTESI M.P., SALMON D., GEI G., PERRE J., EL HACHIMI K.H., FONCIN J.-F. : Alzheimer's disease: a model from the quantitative study of a large kindred. J. Geriatric Psychiatry and Neurology 1992 5 126-131).

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