Hey everyone,
dose somebody also had issues removing the Raney-Nickel after a hydrogenation with dihydrogen? I was reducing a nitrile-function which I can only do by using Raney-Ni.
For workup I used a huge pad of celite and after the column chromatography with DCM/MeOH over silica, still seems that the fractions have some sort of metal complexes ort particle’s.
Would be grateful for some help!
Thanks,
Péter
An option to desactivate Raney -Nickel is to use a solution of H2O2 1% in ethanol or methanol
How do you know you still have Nickel species after column ? You see colorful fractions or particles in suspension ? I would have said that the filtration over celite followed by column chromatography should have allowed you to remove all the Raney Ni. What ratio of MeOH do you use for your eluent ? Typically, if it goes over 20% you'll begin to dissolve silica and you might observe a slightly white suspension...
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