The interactions between cerebral acetylcholine and dopamine systems - intrinsically and in response to pharmacologic manipulation - are complex. There is a very nice article on cerebral acetylcholine and dopamine system interactions that I'd recommend you review as a starting point for the answer to you question:
Lester DB, Rogers TD, Blaha CD: Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neuroscience & Therapeutics 16:137-162, 2010. See http://www.ncbi.nlm.nih.gov/pubmed/20370804, which contains a link to the article full text.
In addition to 'complex' acetylcholine-dopamine interactions compounds like amphetamine (but also methamphetamine, MDMA and mCPP) can exert direct effects on acetylcholine receptors as well as on voltage-gated calcium channels.
Hondebrink et al (2012) Methamphetamine, amphetamine, MDMA ('ecstasy'), MDA and mCPP modulate electrical and cholinergic input in PC12 cells. Neurotoxicology 33:255-260. See http://www.ncbi.nlm.nih.gov/pubmed/21996653.
We have observed a parallel increase in time (1,7 and 15 days after injury) in the expression of genes of D1, D2 and alpha 7 ACh in the rat inner ear. The synapse between inner hair cells and spiral ganglion neurons have a complex system of regulation based on the activity of various peptides and neurotransmitters. We are looking for a reasonable explanation to this finding, Thanks a lot. regards
M. Merchan
- Badges
- Science topic
- Similar topics
- Correction