Eleonore Dorothea Auguste Henriette von Rettberg was the wife of Friedrich Sertürner, who isolated the first alkaloid in 1804; morphine from opium. Did Frau Sertürner die of a morphine overdose? Any leads would be most welcome.
One of his dogs died of an overdose, and possibly some of his probands - including himself - were quite close to. At least, they had serious health issues because of ingesting morphia for test purposes.
See Krömecke, Franz (ed.) (1925): Friedrich Wilhelm Sertürner, der Entdecker des Morphiums. Lebensbild und Neuabdruck der Original-Morphiumarbeiten. Jena