I think the publication in Nature journal is not a big dilemma. Just you need a novel idea and well written manuscript. Of course there are some other parameters could affect the acceptance such as: Author publication history, author affiliation, ect.
I agree with Gomaa - the main thing for the likes of a high impact journal such as Nature or Science (have you looked at the giddy impact factor of Cancer?) is not a biggie - but you have to have something 'unknown/ground-breaking' to report. If you are asking the question 'how can you...' - I would argue that you are not yet ready to publish in these types of journals; you would already know their strict criteria.