For structural biologists, x-ray crystallography is by far the most commonly used tool for unraveling protein structures. It also produces the highest-resolution images of structures. The process typically is performed at cryogenic temperatures to limit ionizing-radiation damage to proteins. How can this study unravel the 3D Enigma of SARS-CoV-2? Thanks.
According to the latest research reports, the crystal structure of the SARS-CoV-2 spike protein receptor-binding domain (RBD) that binds to the host cell receptor ACE2 has been identified using X-ray crystallography technology, which helps deepen understanding of the initial step of SARS-CoV-2 infection at the atomic level. Moreover, the scientists utilized a high-intensity X-ray source to conduct an in-depth analysis of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2. These crystallographic studies are significant for the R&D of antiviral drugs and vaccines.
https://www.nature.com/articles/s41586-020-2180-5
https://www.nature.com/articles/s41586-020-2179-y
https://science.sciencemag.org/content/368/6489/409
The X-ray cristallography determinates the 3D Structure of protein especially the spike protéine receptor binding domain which found at the surface of the virus. This 3D structure of soûle protein could help the researchers to predict using bioinformatic method the therapeutic molecule that interact with it
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