The presence os solubilizing agents in the dissolution media improves the drug dissolution rate. Mixing of co administering of natural solubilzers as lechitine or sodium thaurocholate will definetly improve your dissolution rate.

Dear Pravin, you can add sodium lauryl sulphate in concentration of 0.5 % to improve the dissolution profile of cefpodoxime in dissolution media or otherwise you can go for bio-relevant dissolution media. 

Maybe heating up the solution will help with the dissolution matter.

May the addition of 

You need to improve the dissolution of the tablets, right? Then you can try adding solubilizants into the Tablet formulation. Try some of these approaches:

a) Disperse the active into a melt of Polyethylene glicol 6000 (or mixtures of PEG of diferent molecular weights) and let solidify in order to obtain a solid dispersión; PEG-active complexes have better dissolution rates than the active alone.

b) Granulate the Tablet with molten PEG-6000 can work also.

c) Add beta-cyclodextrin or beta-hydroxy cylodextrines into the formulation. Try dispersing the cyclodextrin in water or water-alcohol solution and add the active with high shear agitation. Then use the dispersión to granulate lactose or cellulose mixtures, dry the granulation and compact into a Tablet.

- Sometimes adding cyclodextrines as dry powders into the Tablet mix or wet granulation can work, mixing active alone with the complexant (cyclodextrin) before the rest of ingredients.

d) You can also add sodium lauryl sulphate up to 0.5-1.0% into the formulation, as dry powder or dissolved into the granulation dispersión (if any).

Best regards

Thanks Luis. I will let u know after trial.

You can try adding sodium lauryl sulphate (concentration up to 3%) into dissolution medium or else you can use solubilizing agents/ disintegrants while compression into extra-granular portion if its wet granulation. If direct compression, it can be mixed with other ingredients. Addition of Tween 80 up to 5% into dissolution medium might also work. 

Can we add surfactant like SLS in compendial method ?

You can add SLS in a compendial method but you must justify the addition, and sometimes this justification is difficult. For this reason is more factible to add it into the Tablet formulation and let the method as is.

SLS and tween 80 into media can be added..or you can directly use water soluble excipients before compression into your blend and then compress it..or grinding your API as well as blend into mixer and then compression will help to improve your dissolution..try media milling method