How can stem cells repair damaged cells?
Could anyone provide papers show the therapeutic potential of stem cells in vitro (on the disease model)?
In general, stem cells can repair damaged cells in both direct and indirect ways but I am familiarised with a specific type of stem cells: bone marrow mesenchymal stem cells (BMSCs). For example, BMSCs secrete solubles molecules which are able to migrate to the damaged area and act (inducing cell growth and differentiation, inhibiting apoptosis and fibrosis...). Also, with cell contact, they can transfer mitochondria to damaged cells and they can induce transdifferentiation and regeneration. Another interesting thing about them is their immunomodulation function: they can supress or induce expression of immune molecules in order to favour a pro or anti-inflammatory environment (that's so important in neurodegenerative diseases in which there is evidence of neuroinflammation).
I don't know if you want papers about BMSCs or something more general, but if you want it, I can send you.
Hope it helps!
In general, stem cells can repair damaged cells in both direct and indirect ways but I am familiarised with a specific type of stem cells: bone marrow mesenchymal stem cells (BMSCs). For example, BMSCs secrete solubles molecules which are able to migrate to the damaged area and act (inducing cell growth and differentiation, inhibiting apoptosis and fibrosis...). Also, with cell contact, they can transfer mitochondria to damaged cells and they can induce transdifferentiation and regeneration. Another interesting thing about them is their immunomodulation function: they can supress or induce expression of immune molecules in order to favour a pro or anti-inflammatory environment (that's so important in neurodegenerative diseases in which there is evidence of neuroinflammation).
I don't know if you want papers about BMSCs or something more general, but if you want it, I can send you.
Hope it helps!
Stem cells have huge potential to regenerate and repair the tissues. Now, to do repair particularly,
-Stem cells can differentiate into specific cell types and do regenerative cum repair.
-It can produce secretory factors that can push the damaged cells to get the repair.
- It can modulate the immune cells which as a result prevents damage and lead repair.
Well, you need to specify or give more details about what kind of repair you are looking for, Wound repairing as wound healing, Skin repair somewhere related to aging, cardiac tissue repair, bone repair, or any tissue or repair.
Check these papers!!!
https://www.frontiersin.org/articles/10.3389/fmed.2019.00011/full
https://www.bbmt.org/article/S1083-8791(07)00581-2/fulltext
Article Mesenchymal Stem Cell Migration and Tissue Repair
Article Advances of Stem Cell Therapeutics in Cutaneous Wound Healin...
Article Stem Cell Therapies for Wound Healing
Article Adipose-derived stem cells for wound healing: HASSANSHAHI et al.
Article Stem cells and growth factors in wound healing
I Hope, this may help you.
Cheers!!!
The therapeutic effect of stem cells (e.g., BM-MSC) is mainly due to the secretory activity through the expression of cell-specific proteins - growth factors, interleukins, etc. So you can apply even the condition medium without cells to obtain a therapeutic effect.
Article The therapeutic potential of mesenchymal stem cell-derived e...
To give more detail, I actually need in vitro studies on the treatment of cells infected by viruses (disease model) with stem cells. Maybe by co-culturing them together...
Saurabh Mandal
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