How has mass spectrometry been applied in research to detect failures in fermentation processes and to characterize cellular state changes, including stress responses, culture transitions, or growth limitations under varying conditions?
I would be glad to hear from your personal experience.
Mass spectrometry detects cellular stress and fermentation failures by profiling metabolites and proteins linked to stress responses. It enables sensitive monitoring of culture changes, growth limitations, and biomarkers to optimize bioprocesses.
In the proteomics world you can perform LCMS/MS analysis of the total tryptic digest. Then apply GeneOntology analysis of detected proteins.
GO: biological process contains different stress responses. It will help if you have quantitative information.
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