How can I write this 2bp substitution mutation located on cDNA position c.67, 68 which changes ATT to TCT nucleotides and I to S amino acids?

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Michael J. Benedik

Assuming you are numbering from position 1 of the start codon from the cDNA, then the norm would be c67A>T;c68T>C assuming that these are positions 67 and 68 in the ORF that are changed. You could always add elsewhere in the sentence or in parenthesis (I>S)

Aissa Saidi

https://atlasgeneticsoncology.org/teaching/30067/nomenclature-for-the-description-of-mutations-and-other-sequence-variations