How can I softly convert amine-group to hydroxy-group into the aromatic core, bypassing diazocompounds?

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What is the procedure of the synthesis of ethylamine from nitroethane?

Please, inform step by step procedure.

31 December 2015 7,016 2 View

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Approximate concentrations are require in compared with the WHO permissible limts

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Baseline drift in HPLC? What causes this?

Hello, Why do i see this baseline drift when i compare my blank (black) to the sample (blue)? Any suggestions as to why this happened? Thank you!

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Geotechnical Engineering (Proceedings of the ICE) time review?

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Basis set and input instruction to calculate HOMO and LUMO using Orca for Imidazolium based organic salts?

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09 August 2024 5,444 7 View

How to confirm the site-directed mutagenesis result without performing NGS?

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How to calculate CCS for Sodiated adduct ions and Multiply Charged Ions?

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Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

Why my colony PCR results of my recombinant bacterial not showing any results?

I am performing ligation of the plasmid and a target gene. The steps I have taken are: 1. Double digestion of the plasmid and target gene 2. Ligation of the plasmid with the target gene 3....

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Low-yield gel extraction problem?

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How to convert g/kg Humic acid dose to kg/ha?

I used humic acid at 0.044 g/kg soil in my pot experiment. But finally, I have to recommend kg/ha. Each pot's soil weight was 11 kg. What is the solution?

02 August 2024 7,186 6 View

Andrei Rogoza

The only (non-diazonium) example was found in transformation

6-methoxy-1-naphthylamine + NaHSO3; +NaOH -> 6-methoxy-1-naphthol

J. Am. Chem. Soc., 1961, 83 (24), pp 5015–5019

DOI: 10.1021/ja01485a031

Triflation to Ar-N(SO2CF3)2 or transformation in N,N'-aryl(alkyl)imidazolium salt may be also is a solution for N-umpolung

@Michael: thanks for valuable add-on. My answer was updated. If you have examples to demonstrate, please do not hide them from us

Sandip Vibhute

Bucherer reaction

Yes, sure, Sandip, thanks for reminder!

Bucherer, H. Th. (1904), Über die Einwirkung schwefligsaurer Salze auf aromatische Amido- und Hydroxylverbindungen. J. Prakt. Chem., 69: 49–91. doi: 10.1002/prac.19040690105

Vladimir Loza

My fastidious transformation in the attached file.