How can I select oral doses [3 doses--lower, moderate and high doses] of extracts from LD50?

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Milan Jokanovic

The highest dose shall be the one that decreased body weight by about 10% in single dose toxicity study. The lowest shall be near proposed pharmacotheraputic level. The third dose shall be in the middle between other two.

Good luck with your research.

Alain Bousquet-Melou

Hello,

I have attached a pdf file in which I describe a way to calculate doses.

It can be applied ONLY IF the same animal species AND the same route of administration are used for estimating LD50 and for your new experiment.

Sincerely yours,

Alain Bousquet-Mélou

Mallappa Shalavadi

Thank you sir