Hello,
I have some problems with removing diphenyl phosphoryl azide (DPPA) from the reaction mixture. I am using DPPA to convert the acid carboxylic group to isocyanate, using toluene as a solvent of reaction. During the work-up, I use ethyl acetate to extract my product from the aqueous phase. In the next, I wash the organic phase with HCl 2.5%, H2O, and brine. Finally, I remove the solvent using the rotavapor. Does someone suggest another type of work-up?
My product is soluble on toluene, THF, dichloromethane, and ethyl acetate.
Best regards,
Sara Moura
Dear Frank T. Edelmann, thank you for the recommendations. I will complete the question with more information.
Dear Sara Moura it depends if you product is a liquid or a solid. In the latter case you could try recrystallization of the crude product. According tho the attached article, the reagent DPPA is a liquid.
Hi Sara Moura, during the work-up, you can partition the resulting solution with H2O and CHCl3.you will separate the organic phase and wash with 5% of Na2CO3 and brine solution.
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