During the last year, a patient with desminopathy (Thr341Pro DES mutation) was found to have a 1.8 to 20-fold decrease in the level of circulating immune complexes, a 1.3-fold decrease in B-lymphocyte counts, and monocyte phagocytic activity increased 1.4-fold.
In the immune status, the patient has an increase in the relative and absolute number of cells with apoptosis markers over the past six months: an increase in CD95 + T-cytotoxic lymphocytes is 6.5-6.6 times; CD95 + T-lymphocytes in 3,3 - 3,7 times; CD95 + T-helpers in 2,1 - 2,4 times; CD25 + activated T-lymphocytes in 3,5 - 3,7 times; HLA-DR + activated T-lymphocytes in 3,2 - 3,8 times. At the same time, the number of T-killers (T-NK) decreased by 1.8-2.0 times, and the immunoregulatory index decreased 1.5-fold.
What can be done in this case to slow the progression of desminopathy?
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