Hello everybody: Please I need to help me with this fact. We are making HAP ( hydroxyapatite) but we now need to make nano- HAP . Anybody known how we can reduce the size. The process is a sol-gel process.
Pablo Bonilla Valladares Hi. commercial hydroxyapatite is very heterogeneous with respect to size. You could do differential centrifugation to isolate the HP size you are after.
Firstly, I will say that as it comes out from the State of the Art, the dispersion of aggregates of hydroxyapatite fillers containing primary nanoparticles of nanometre size could be a difficult process, thus an impressive number of studies are dealing with this topic.
Regarding your question connected to the preparation of hydroxyapatite nanoparticles by sol-gel method, please consider below some references that can help you to find the best techniques.
Good luck and best regards,
Marius
For info & eventual help:
Preparation of hydroxyapatite nanoparticles by sol-gel method with optimum processing parameters, AIP Conference Proceedings 1660, 070054 (2015); https://doi.org/10.1063/1.4915772 https://aip.scitation.org/doi/10.1063/1.4915772
Characterizations of hydroxyapatite (HAp) nanoparticles produced by sol-gel method, October 2013, Advances in Environmental Biology 7:3587-3590 http://www.aensiweb.com/old/aeb/2013/3587-3590.pdf