That is a somewhat complex question. On the one hand there are a number of MOFs which do exhibit excellent stability in aqueous media like most of the MILs and many of the Zr-based MOFs and also the ZIFs. That would be the strategy of creating a MOF whose metal-linker bonds exhibit hydrolytic stability to some degree. In most cases, however aqueous basic media are a problem. On the other hand, a less stable MOF (bondwise) can be passivated  to various extents by adding hydrophobic side groups to the linker. There has been some investigation in the group of Krista Walton dealing with substituent effects on pillar-layer MOFs and a number of works deal with hydrophobization of MOFs like HKUST-1. So if you want to work with a less stable MOF, you would have to prevent water accessibility to the metal-SBU by some means.

Thanks Stella, so you work with Setefan Kaskel

Hey Hiram, nice to give you the contact info of Alma Olivos Suarez

 http://cheme.nl/ce/people/alma.html

[email protected]

Ella es especialista

suerte 

Gracias Pedro, gusto en saludarte también.

There is this fantastic review on water stability by Dr. Krista Walton's group you can read... There you will find a lot of strategies like:

• using hard acids (metal cations Zr4+, Cr3+, Al3+)
• using high pKa ligands 
• hydrophobization of the MOF by adding methyl groups on the ligands
• minimizing the rotation of the benzenes of ligands 

And more. But it all has to do with what you want to do... Please do explain what you want to synthesize. Maybe people can suggest routes of doing so if they know the target structure. 

Thanks Prof. Xydias, sorry for my very delayed answer. I will revise the reference that you kindly provide me. Best regards. Hiram