My reaction is amide to nitrile. I used thionyl chloride for the conversion.And during the neutralization of the medium it takes so much of base and still it's acidic. Am I doing it correclyt?
Thank you.
Add small excess of cooled EtOH. Et-Cl and SO2 as gases will be formed. Work in digestory!
This is possible also with cooled methanol. Obligatory in ventilation hood.
try to evaporate thionyl chloride (b.p. is around 74) after the completion of reaction, u may get ur product, which then u can neutralize easily.
it is better to distilled out product if having low BP , and then neutralize the product.If high distilled out TC, and then neutralize the product.
Thionyl chloride (SOCl2) reacts (exothermically) with water: (i) SOCl2 + H2O → 2 HCl + SO2. It can be distilled off from water-free reaction mixture under vacuum, say, by around 40 ºC. As guideline for the required level of vacuum, I have estimated the vapour pressure of SOCl2 as 29 kPa at 40 ºC. You may consider bubbling the non-condensed SOCl2 vapour trough a trap containing cold (or icy) alkaline brine (e.g. NaOH aq.), where both SO2 and HCl can quantitatively dissolve and be neutralized after being generated by reaction (i). I would suggest to further protect the vacuum pump (e.g. by a filtering system with good adsorption capability). Alternatively, we could dispense such additional protection by substituting a water aspirator for the vacuum pump, as that seems enough to attain a sufficient level of vacuum.
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