Mazin Nadhim Mousa If as you said your polymer is insoluble in any solvents, sorry, you will have problems first to load it with hydrophobic or hydrophilic drugs and second, to make the water solution that allows its administration.

Good question I follow

You can try to dissolve your polymer and drugs in chloroform or other solvents. Then rotary evaperation can be used to get a thin film. Post buffer addition and sonication, you might obtain nanoparticles with drug inside.

Dear Mazin,

For me is not very clear the information regarding the biopolymer that is concerned by your research. Firstly, do you have the confirmation that it is biodegradable?

Regarding the good solvents, maybe for instance you didn’t find the adequate one or the polymer is reticulated, because this could explain the problems of solubility.

A good starting point it is to check the Hansen solubility parameters (Hildebrand solubility parameter) that are specific to your polymer and to try to find adequate solvents.

Regarding the other methods to load the polymer with model drugs, in some cases the hot melt extrusion (HME) could be a technique of interest and an alternative for consideration…

Good luck in your R&D work and best regards,

Marius

The modification of polymers is a promising technique for the making a new materials. The productive method can change common polymers so as to synthesize natural-based greatest absorbent polymers. Natural polymers are modified as a means to overcome their setbacks such as drop in viscosity, microbial degradation, and partial or low solubility. In addition, modification of natural polymers enhances their drug delivery characteristics and versatility. Modification of polymers should be undertaken such that the natural polymers do not lose their biological properties. The methods of modification include grafting, crosslinking, The chemical modifications of the natural polymers using initiators, shows promising modification to develop and transfer desired characteristics.

you can used the following references

References

=-Firyal M.A.Al-salami Sana.HAwad Gelatin Grafted Methyl Nadic Anhydride and Substitution With Salbutamol Second National Conference of Chemistry20-21 .November 2

=-Firyal M. Ali and ,Mohammed A. Farhan ( 2017) SYNTHESIS OF SUBSTITUTED STARCH GRAFTED METHYL NADIC ANHYDRIDE AS DRUG COPOLYMER, EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH ejpmr, ,4(5), 81-88

=-Firyal M. Ali and Mohammed A. Farhan Synthesis of Substituted Starch Grafted Methyl Nadic Anhydride as Drug Copolymer European Journal of Pharmaceutical and Medical Research81-88

April

=--Fiyral Mohammad Ali --- Taghreed Hashim.AL-Noor , Saif Mohsin Ali (2015). Lactic Acid as Spacer between Poly Acrylic Acid and 4- Aminoantipyrine. The International Journal of Biotechnology, 4(6): 36-45. DOI: 10.18488/journal.57/2015.4.6

=-Firyal M., Sana H. and Mena M., Synthesis of substituted gelatin grafted maleic anhydride as drug copolymer , Chemical and Materials Research Vol.7, No.5, P.1-8, (2015) .

=-Firyal M., Firas A. and Ahmed Y., Synthesis of prodrug ciprofloxacine procaine male amide, Polymer Iraq National Journal of Chemistry (NJC), Vol.56, P.416-425, (2014).

=-: Firyal Mohammed Ali Alsalami*. Gelatin grafted with drug. Asian Journal of Green Chemistry, 2018. DOI: 10.22631/ajgc.2018.102291.1034 Volume 01, Issue 01 (August. 2018), PP 01-06 www.ijmsdr.org

= -Firyal M.A. and Saif M.A., (Synthesis and characterization of new (N-Ethyl Acrylamide Mefenamate), Babylon university journal, Vol. 23 (5), (2015). Advances in Life Science and Technology www.iiste.org

=-Firyal M.A. Saadoon A.A. Faris H.A.M. Synthesis and Characterization of Novel ProDrug Polymers and Their Controlled Release

ISSN: 0974-2115 www.jchps.com Journal of Chemical and Pharmaceutical Sciences

JCPS Volume 10 Issue 3 1 July - September 2017

=-Firyal Mohammed Ali* and Ahlam Fraih 2AL-Shihani and Wessal M. Khamis Grafting of Polyethylenglygol with Some

=-: Firyal Mohammed Ali Alsalami*. Gelatin grafted with drug. Asian Journal of Green Chemistry, 2018. DOI: 10.22631/ajgc.2018.102291.1034 Volume 01, Issue 01 (August. 2018), PP 01-06 www.ijmsdr.org

=-Firyal Mohammed Ali and Mohammed Alwan Farhan,Preparation of Starch Grafted Methyl Nadic Anhydride and Substituted

with Amino Drug 📷Vol: 13 No:4 , October 2017 242

=

=- Firyal M.A. and Hameed M.A., (2018).,pectin of release controled drug ,Journal of Drug Delivery & Therapeutics; 8(5-s):215-222.

= -Firyal M.A. Hameed M. A, (2018). Modification of Pectin-Glycine with Indomethacin to treatment the wound and inflammations . International Journal of Medical Science and Dental Research.

It sounds as if you have a crosslinked polymer.

If so you could search for a solvent which swells your polymer and dissolves your drug. Swelling of the polymer in a drug solution followed by drying could result in a drug containing polymer but for this pathway it is difficult to control the drug load in most cases.

A second way could be to add the drug before polymerization/crosslinking of the polymer. In this case you should check if the drug reacts with the monomers or intermediates during polymerization/crosslinking.

Good luck for your experiments.

Best regards,

Roland

You can load the drug in a batch procedure where the polymer is swelling in the solution of drug, by stirring in different times, then determination of the remanent drug in the solution by different methods, UV, etc, gives you the drug load retention indirectly.

I want to show my two ideas for you:Firstly,you can store the drugs in the polymer network(you described it insoluble,so i guess)by a physical way; secondly, you can graft the drug molecules in a chemical swith such as the UV and so on。Many papers are available for you research.