Hi,
We are going to carry out a pharmacogenetic research on CYP2D6 and CYP2C19 variants. We have already selected our suitable variants but I was wondering how can I select my appropriate SNPs?
Is there any database for finding out all SNPs of a variant? And generally in pharmacogenetic studies, how are SNPs selected? By their frequency or their effect or something else?
Thanks in advance for your answers!
Hello Hossein,
I usually research on SNPedia (https://www.snpedia.com/index.php/SNPedia) and NCBI (https://www.ncbi.nlm.nih.gov/projects/SNP/) databases for SNP characteristics, sequence and frequency. In respect to pharmacogenetics, there is a very rich database called PharmGKB (https://www.ncbi.nlm.nih.gov/projects/SNP/), which presents a lot of clinical support to SNP importance. I hope that this helps you. Good research!
Hi Hossein,
Probably you may find these links helpful in addition to PharmGKB mentioned by Eric.
http://www.cypalleles.ki.se/
http://bioinformatics.charite.de/supercyp/index.php?site=cyp_snp
NCBI/SNP is very good of course. You may also like to look at Uniprot.org....
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