https://patents.google.com/patent/EP0387725A2/en

Are you trying to make the bis-amide, or the bis-benzoxazole? The latter process is well-known (attached patent.)

you have both the reactive groups like phenol and amine, which product you are expecting after condensation either amide or ester?

I am trying to synthesise a benzoxazole structured compound with the condensation of o-amino-2-methyl phenol or o-amino phenol with thiopene 2,5 di-carboxylic acid.

Following below attachment is the structure of my final product.

Example 5 of the patent I enclosed describes that very compound. (CAS RN：7128-64-5)

It's commercially available from numerous suppliers; unless you need a lot of it you might want to simply buy it.

Thankyou Sir For Sharing This Valuable Information James Demers .

Do esterification/acid halide conversion (with equimolar ratio) of carboxylic acid first followed by careful addition to amine. Works well for amide preparation without affecting alcohol functional group.

https://www.sciencedirect.com/topics/chemistry/benzoxazole

Dichloromethane/THF is more preferrable for trans esterification followed by amine coupling.

Thankyou Krishna Reddy

hello Daniyal

you can try this reaction of o-amino phenol condensation with thiopene2,5 dicarboxylic acid with different heterogeneous solid acid like Amberlyst and another you can be used cyanide grp instead of acid