This link maybe useful

https://www.rdocumentation.org/packages/ic50/versions/1.4.2/topics/ic50

ic50: Standardized evaluation of cell-based compound screens in ic50: Standardized high-throughput evaluation of cell-based compound screens

https://rdrr.io/cran/ic50/man/ic50.html

You may also have a look into the drc package:

https://cran.r-project.org/web/packages/drc/

Article Dose-Response Analysis Using R

https://docs.ufpr.br/~taconeli/CE06219/Artigo2_Mod3.pdf

http://www.darrenkoppel.com/2020/09/04/dose-response-modelling-and-model-selection-in-r/

https://rstudio-pubs-static.s3.amazonaws.com/378543_5b5bda32bf0541a485ccc49efbea680a.html

PS: RStudio is "only" a graphical user interface. This is not the tool doing the analysis, it does not calculate anything. It only allows you to cenveniently interact with R. The actual analysis is done in R. It does not matter which interface you use to tell R what to do.

Proloy Barua Jochen Wilhelm Thank u so much!

drc package is very good for the calculation of IC50s or even other relevant ICs such as IC10 or IC90.'If you have a dataframe called my_df with three columns, such as the strain drug and cell_viability the following steps would do the trick.

Step1: Create the model

drc_model