How can I generate random samples from Bingham distribution in R? How can I construct those symmetric matrices?

in the function rbingham(n,A) in R software how can I construct that A (symmetric) matrix?

24 February 2021 3,528 3 View

How Shall I perform Principle Component Analysis in GROMACS?

I have to perform PCA as a part of my results and analysis of protein-ligand complex docking using GROMACS 2018.8. How shall I perform PCA and interpret the results for the same? Any insights...

13 December 2020 3,121 2 View

How shall I prepare a protein PDB file in a particular pH for docking and simulation?

I wanted to prepare a protein at an alkaline pH for molecular docking as that is the pH I want to perform my in vitro assays in? I prepared my protein at the required pH through H++ server;...

13 December 2020 2,272 3 View

How can i increase biomass of my E. coli culture to better plasmid yield?

Hi everyone, I want to increase the biomass of my E. coli culture for better plasmid yield. Use of different strains of cells and media or any other suggestions are welcome. Thanks!

11 October 2020 6,400 3 View

Has chemistry Nobel Prize really become the biology prize ??

07 October 2020 8,119 6 View

Which of the five PDB files (DRGFIN.PDB, DRGMMX.PDB, DRGNOH.PDB, DRGPOH.PDB & DRGAPH.PDB) as an output from PRODRG Server do I need to use?

I have some protein-ligand complex to simulate on GROMACS version:unchecked. For preparation of my ligands, I submitted the extracted Ligand.pdb file and submitted it in the Prodrg server, Energy...

01 September 2020 9,154 5 View

Can anyone please enlighten me, that what are free in silico toxicity prediction software/s available for academic purpose ?

Free toxicity prediction software based on genetic algorithm and deep learning of some training dataset #toxicity #Freesoftware #insilico #Deeplearning

30 August 2020 7,950 4 View

Do you have the following alloys?

Dear colleagues, It will be a great help if someone can provide me small pieces (1.5 cm * 1.5 cm * 1.5 cm) of cast Al 5024 alloy and Al 7068 alloy (with and/or without T6 heat treatment. Happy to...

31 July 2020 3,593 1 View

What to do when there is no main or interaction effect but multivariate tests and pairwise comparision tables show significance?

I run repeated measures ANOVA for an intervention study. I have 3 intervention groups and 3-time points. The output in SPSS showed that there is no significant main effect of time and no...

02 April 2020 2,328 7 View

Can metal polymer sandwich material system be applied for biomedical application?

What are some some recent trends where metal polymer sandwich material system can be an effective alternative in biomedical?

20 January 2020 6,434 2 View

What is the production process of CaFe ferroalloys?

I looking for ferro calcium production process

03 March 2021 1,755 4 View

What are difference between laser diodes, simple light emitting diodes and power light emitting diodes when operated in the visible spectrum ?

I want to illuminate a scene (small space) using LED to capture photographs or videos of some tiny objects inside the space. But am not sure if I should use a Laser LED, or simple LED or power...

22 February 2021 4,240 4 View

No title

Hello. I ask for help - I need to get lithium tetraborate (soluble salt) from lithium carbonate and boric acid. In literature, everything seems to be simple - mix, ignite and - it's done. But it...

16 February 2021 9,523 2 View

Purified protein requires Calcium for activation, but the elution buffer I used seems to interact with Calcium, help?

09 February 2021 6,946 4 View

Why am I getting such large heats of dilution in my Isothermal Titration Calorimetry Experiment?

I am trying to measure binding of calcium to an expressed protein we are studying and am getting very large heats of dilution for the calcium solution in my control tests. We prepared a 1 M CaCl2...

07 February 2021 7,532 1 View

Which sphygmomanometer is suitable for teaching practicals in Physiology, Android or Non-Mecurial LED Sphygmomanometer??

Recently MCI now NMC has made it mandatory to use only Non mercury Sphygmomanometer for teaching practicals to MBBS students. So I want ask which is technically better option, Android or...

03 February 2021 3,795 4 View

How can you accurately induce calcium overload and measure membrane potential in cultured Tg2576 neuronal cells using whole cell patch clamp method?

Hi there, I'm currently working on a project where i need to design an experiment but as i have little to no experience with this level of experimental design and no face to face help i am really...

22 January 2021 6,728 3 View

Why calcium oxide nanoparticles becomes black at 650 degree temp?

Please tell me, which temp can I select for neglect black color of the Calcium oxide nanoparticles ..

14 January 2021 5,341 5 View

What acid can be used to dissolve limestone to extract microfossils?

I am trying to extract possible Loriciferans from mudstone, attempts with acetic acid (15%) and chloridric acid (37%) have failed to dissolve the rock, would a higher concentration (50%) of HCl...

17 December 2020 5,897 7 View

How to quantify/detect change in fluorescence in calcium images from different sessions?

Hi, I have 2 3d tiff stacks collected by imaging along axial plane of mouse brain area in vivo from different days, before and after fluorescent viral injection. I want to detect changes in...

10 December 2020 5,046 3 View