Thank you for your question. Histopathology often provides crucial information that is not accessible through other methods. It helps identify the underlying pathology in AKI, including changes in kidney tissue such as acute tubular necrosis, interstitial nephritis, glomerulonephritis, and vascular changes. It assesses the extent and nature of the damage, including chronic changes that indicate a prolonged process. The identified changes can influence the choice of treatment and prognosis.

As for limitations: histopathology requires an invasive procedure with certain risks, including infection and organ damage. Moreover, this method can be time-consuming, requires specialized training for pathologists, and is resource-intensive.