Hello everyone,
My colleague and I are working on creating a protocol for examining tendon mechanical properties, but are having trouble finding a description of how tendon fibrils are isolated. We have worked with muscle tissue isolation before, but since there is a big discrepancy in size (10-50 microns vs 50-500nm) we are unsure what exact tools are needed for this type of extraction. Does anyone know of a paper with a detailed description of the process, or can someone share their experience with this type of tissue?
Isolated fibrillar damage in tendons stimulates local collagenase mRNA expression and protein synthesis
As I understand, the location of tendon from which fibril is isolated tendon (i.e., achilles or flexor) and hydration status of fibril will change the diameter and hence the mechanical properties. Age of animal or human etc need to be consistent, the dia will differ under such instances
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