Dear all,
We'll soon start to apply questionnaires analyzing the impact of anticoagulants during pregnancy on the offspring's behavior and learning skills. The inclusion criteria is either heparin use for at least the first seven months of pregnancy or warfarin use from 14 to 36 weeks of pregnancy (e.g. mothers with mechanical heart valves or with biological heart valves and atrial fibrillation). The kids must be 7 to 15 years old and controls will be matched by neighborhood.
Let me know if you want to join our team and I'll send you the rationale and the methodology. Thank you in advance,
Silvia Hoirisch-Clapauch
Dear Giuseppe, We assumed that anticoagulation improves placental angiogenesis and vasculogenesis, without correcting metabolic issues that could impair intrauterine neurogenesis. Also, nobody knows the effect of anticoagulants that cross the placenta on the fetal brain.