Hello 

calcineurin inhibitors have been shown to abrogate the immunosuppressive effect of rat MSC therapy . SO , It is very important to choose the appropriate drugs in combination with the adoptive stem cell-mediated immunotherapy . In organ transplantation involves the administration of calcineurin inhibitors, such as cyclosporine A (CSA), tacrolimus or mycophenolate mofetil (MMF). These drugs might interfere with the immunosuppressive effects of hMSCs after adoptive transfer.

to explain this I will describe to you some researchers attempts :

Le Blanc were the first to show an in vitro synergistic effect of CSA on the hMSC-mediated immunosuppression of T-cell reactivity. However, by contrast, Buron et al. observed that CSA, tacrolimus and rapamycin antagonized hMSC inhibitory effects, whereas MMF promoted the hMSC inhibitory effects. In addition, Eggerhofer et al. demonstrated in a rat model of heart transplantation that MSCs and MMF synergistically prevented infiltration of APC and T cells into the graft.

Hope these  help you.

Best wishes

Thank you for Your opinion

you are welcom .

Best wishes

Hans Klingerman was the medical director for osiris's trial using MSC for resistant GVHD, if anyone knows an answer to your question he would be the one to ask.  I know as of 2 years ago he was still with the company but not sure now.