I already have 30 sample. I want to also know if we want to analyze the gene polymorphism in rare diseases and we don't have enough sample which other methods rather than case/control study should be used.
Thank you
You definitely want to do a case-parents trio study. Here is a review, which demonstrates that the association power is stronger in case-parent trios than case-control studies when disease prevalence is rare.
http://www.nature.com/nrg/journal/v7/n5/full/nrg1839.html
Hi,
as Jan said, searching for analyzing rare disease with so poor prevalence is not suitable with cases/controls study. Familial studies are best, trio is a major way to manage genetics background correction. You need now to recruit the families and why not in case of large families run linkage analysis.
best luck
fred
Thank you so much. Actually the problem is I can't use GWAS because of lack of research facility. Is it necessary to utilizing GWAS for case-parents trio study?
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