Hi, I have to perform dissolution on USP Dissolution Apparatus 2, so I can add nanoparticles in basket?

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Looking for help.

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Hi, can anybody tell the advantages and disadvantages of dialysis method of preparation of nanoparticles?

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Whats the effect of miscibility of organic solvent with non solvent on physicochemical properites of nanoparticles?

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Hi, can anybody provide article on comparison of nanoparticles with other drug delivery systems ?

Thank you

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To analyze the size of Ethyl cellulose and HPMC nanoparticles by zetasizer, how to redisperse them and in which medium these should be redispersed?

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Is it wrong to evaporate 5ml Dichloromethane in few seconds by reducing the pressure of the rotary to zero? I am preparing polymeric nanoparticles?

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Hi, How to find drug content of nanoparticles?

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Mubashar Rehman

No. You will place your nanoparticles in dialysis membrane available in the form of tubes and cassets. These nanoparticles filled systems will be placed in dissolution medium. If you place nanoparticles directly into disssolution medium, they will get removed when you take samples.

https://www.thermofisher.com/pk/en/home/life-science/protein-biology/protein-purification-isolation/protein-dialysis-desalting-concentration/dialysis-products/slide-a-lyzer-dialysis-cassettes.html

http://www.sigmaaldrich.com/labware/labware-products.html?TablePage=21942948

These are two examples. Please ask you supplier to find best options.

Giulia Fulias

Yeah right, thank you. How much does dialysis membrane cost?

My pleasure. Price depends on supplier you selected.

Himanshu Bhatt

Dialysis membrane does not give true release in many case.

Take media volume according to your drug detectability and directly suspend your NP into it and place it on bath shaker. Withdraw your sample periodically using syringe filter if necessary.