Is it wrong to evaporate 5ml Dichloromethane in few seconds by reducing the pressure of the rotary to zero? I am preparing polymeric nanoparticles?

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Rishabh Srivastava

Very fast phase separation may lead to precipitation of polymer. But using rotary evaporator is a nice idea. Be cautious and you may try it.

Giulia Fulias

What will happen if polymer will precipitate?

Chella Naveen

Rapid evaporation results in precipitation of polymer or formation of more porous particles resulting in very low entrapment efficiency and higher size distribution.

Thank you guys.