Is Colistin resistance a problem associated with gram-negative bacteria in particular?
Gram positive bacteria are intrinsically resistant to colistin. So it is not a treatment option for gram positive.
For gram negative bacteria, it is a last resort antibiotic for many of them. However some gram negative also has intrinsic resistance like Proteus, stenotrophomonas and Burkholderia.
i don't think so.. In my lab i m getting good rate of sensitivity of colistin against Gram negative bacteria.
Colistin acts as a third line of antibiotic towards gram negative bacteria. There are increasing reports of growing resistance to this antibiotic as well.. It is ineffective for gram positive microbes
Ahmed Elsadek Fakhr , Sweta Singh , Aklima Akter
Thank you for your feedback, I really appreciate your interest in the question
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According to (Torres et al. 2021), Due to its mechanism of action, colistin is highly effective against most Enterobacterales species and non-fermenting Gram-negative bacteria such as Acinetobacter baumannii and Pseudomonas aeruginosa. Conversely, colistin is not active against Gram-positive bacteria, Gram-negative cocci, and anaerobic bacteria. Some Enterobacterales species are intrinsically resist-ant to colistin, such as Serratia marcescens, Morganella morganii, Proteus mirabilis, and Burkholderia spp. due to the constitutive expression of genes that lead to the modification of the LPS and an increase in its charge
Source: Article Colistin resistance in Gram-negative bacteria analysed by fi...
It is used currently as a last-line drug for infections due to severe Gram-negative bacteria followed by an increase in resistance among Gram-negative bacteria. Colistin resistance is considered a serious problem, due to a lack of alternative antibiotics. So they are resistance mainly by Gram negative bacteria because they are ineffective against Gram positive bacteria.
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