Can 1 1′-bis(diphenylphosphino)ferrocene dichloropalladium(ii) be used instead of 1,1′-bis(diphenylphosphino)ferrocene as a catalyst in organic synthetic reaction involving replacement of Bromo- by an acetyl- group?
I believe Pd(II) role in the compound as a catalyst will be crucial. As palladium itself is a good catalyst. I will suggest you getting the right compound as reported in literature for the reaction. Thank you.
Hi Ehtesham Mohammed, I agree with Segun Daniel Oladipo. The additional palladium could have a beneficial catalytic effect on your reaction. Perhaps you even get better yields.
Well, without being a speciatlist at that field, there are three options at this point:
#1: If that's a question that does not allow you to fall calmly asleep at night, and you have got both substances on shelf - just give them a run. That's the beauty of science that any concept can be tested. If you find something exceptional - you will have an option for new and interesting publication.
#2: If you have the shortages of the first reactant, you are in hurry and you have a second one on in your hands - just try what you've already got. In my opinion, depending on the chemistry both of them might be efficient, but for me is quite tricky to predict your outcome without knowing exactly your reaction/process conditions.
#3: If it turnes out (or you suspect), that both reactants have comparable efficiency, and you think about the large scale process, I just think myself: What would be the purpose of using more expensive catalyst, containing precious metal inside?
Hi Ehtesham Mohammed,
We should agree with answers of S. D. Oladipo and F. T. Edelmann. Pd(II) catalysts finds crucial role in catalysis. Hence, 1 1′-bis(diphenylphosphino)ferrocene dichloropalladium(ii) can be used instead of 1,1′-bis(diphenylphosphino)
ferrocene. Also I suggest you carry out yours work with trans PdCl2(tpp)2 which may also hopely gives you wonderful result. Thank you.
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