Google is your friend: http://bfy.tw/D1sw

https://www.agilent.com/cs/library/slidepresentation/Public/AFM%20Imaging%20in%20Liquids_Travis%20Johnson_1107.pdf

Do you mean AFM measurements in liquids or AFM measurements of liquids?

If its the former then its easy, basically just immerse the cantilever and surface in the fluid of interest, allow thermal equilibrium to be attained (IT may be an idea to turn the laser on for  30 mins or so before you actually take measurements to avoid excessive thermal drift, and then use the afm in the normal way. One point to ensure is to ensure that the top surface is not a liquid air surface but a liquid transparent solid surface (such as glass) I suspect that the instrument you will be using that this is likely to be the case.

If you have the top surface as a liquid surface then the laser gets affected by vibrations and or capillary waves.

It turns out that afm in liquids is in many respects easier than in air as the liquid damps vibrations. If you plan to do force spectroscopy then do not move the surfaces together too fast 1 micron a second is OK but faster gives hydrodynamic bending of the cantilever (the exact speed where this is noticeable will depend on the spring constant)

If you mean the later good luck, I do know a few people who have tried but not seen anything published.

Paul

I got two MultiMode afms an as far I know, even if here is possibility to make measure in liquids it is dangerous for scanner, because liquid usually flow down and scanner is below sample (construction of MM). Better choice is ANY system which has scanner upper the sample. Take look at X, Y, Z scales and choose the best for your application.