Is it possible to use extraction at 200 centigrade degrees (by accelerated solvent extraction method) to remove lentinan which is damaged at 130-145 centigrade degrees?
sorry to see that your interesting technical question has not yet received any qualified answers. I must admit that as an inorganic chemist I'm not a proven expert in this discipline. However, I can suggest to you the following useful review article which could provide you with some initial ideas:
Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
Article Development of Mushroom-Based Cosmeceutical Formulations wit...
This article is accessible as public full text on RG. Thus you can freely download it as pdf file.
Please also have a look at the following interesting link which shows that shiitake mushroom extract and lentinan are indeed beneficial to the skin:
P.S. There are also a number of potentially useful articles available in the literature which describe in detail the extraction of lentinan from shiitake mushrooms. In this context please have a look at the following relevant literature references:
An Improved Method for the Isolation of Lentinan from the Edible and Medicinal Shiitake Mushroom, Lentinus edodes (Berk.) Sing. (Agaricomycetideae)
Article An Improved Method for the Isolation of Lentinan from the Ed...
Lentinan extraction process from mushrooms using ionic liquid
Variation of Bioactive lentinan-containing preparations in Lentinula edodes strains and stored products
Article Variation of Bioactive lentinan-containing preparations in L...
In addition, I strongly suggest that you search the "Publications" section of RG for other helpful articles. Just search for terms like "lentinan extraction" and the click on "Publications". You will be surprised to see how many RG members have already posted relevant research articles about this topic.