Both ANSYS CFX and ANSYS Fluent provide in their Eulerian multiphase flow models the options for modeling interphase slip (drag) by using the drift-flux formulation. In ANSYS CFX it is a bit hidden, because it is implemented as an option in the context of the multi-component mixture formulation. It became rarely used. Most of the time people prefer to model interphase drag by making some assumption about the multiphase flow morphology and coming up with some explicit drag term formulation (and corresponding drag coefficient).
According to Shi, H., Holmes, J., Durlofsky, L., Aziz, K., Diaz, L., Alkaya, B., and Oddie, G. (2005). Drift-Flux Modeling of Two-Phase Flow in Wellbores. SPE J., 10(1):24-33., DFM is used in several reservoir simulators. Names of the simulators and references can be found in the article.
Ghassan Fadhil Smaisim : but on the other hand side ANSYS CFX is usually converging better and faster for complex multiphase flow applications, than ANSYS Fluent does.
I just wanted to add that ANSYS FLUENT can simulate multi-phase flows based on DFM (drift-flux model) ... in a sense.
ANSYS FLUENT has DFM option in it, but in a weird way. First, they call it not DFM, but mixture model (by the way, two-fluids model they call Eulerian model). The basic set of DFM equations is more or less standard (momentum and energy for mixture, one continuity for mixture and one continuity for dispersed phase). But instead of slip relation (either in Zuber form or in Ishii form) they use, some not so common relation for relative velocity between phases. Also, I failed to find what they use as a closure relation to connect density and pressure (it is an important problem in transient flow simulation based on DFM). Regarding high DFM sensitivity to different gas-liquid flow regimes, they also have relatively uncommon (even questionable) recommendations (https://www.afs.enea.it/project/neptunius/docs/fluent/html/th/node294.htm#sec-mphase-intro-choosing-details).
Overall, this is ANSYS FLUENT guide to multiphase flows modeling (https://www.afs.enea.it/project/neptunius/docs/fluent/html/ug/node718.htm) - the guide is pretty scattered, so it might take a while to find every piece of information one might need.