Dear Farhad,

Maybe the following papers will help you on the subject:

Tee JM, Peppelenbosch MP. Anchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiology. Crit Rev Biochem Mol Biol 2010;45(4):318-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942773/pdf/bbmg45-318.pdf

Lowe AR, Itzhaki LS. Rational redesign of the folding pathway of a modular protein. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8): 2679-84. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815241/pdf/zpq2679.pdf

Das B, Young D, Vasanji A, Gupta S, Sarkar S, Sen S. Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure. Cardiovasc Res 2010;87(3):524-34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904660/pdf/cvq068.pdf

Wang Y, Chen J, Song W, Wang Y, Chen Y, Nie Y, Ye Z, Hui R. The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension. PLoS One 2015;10(8):e0135526. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537090/pdf/pone.0135526.pdf

Shiraishi S, Nakamura YN, Iwamoto H, Haruno A, Sato Y, Mori S, Ikeuchi Y, Chikushi J, Hayashi T, Sato M, Cassens RG, Ito T. S-myotrophin promotes the hypertrophy of skeletal muscle of mice in vivo. Int J Biochem Cell Biol 2006;38(7):1114-22. https://www.sciencedirect.com/science/article/pii/S1357272505003936

Hayashi T, Ogawa T, Sato M, Tsuchida N, Fotovati A, Iwamoto H, Ikeuchi Y, Cassens RG, Ito T. S-myotrophin promotes the hypertrophy of myotube as insulin-like growth factor-I does. Int J Biochem Cell Biol. 2001;33(8):831-8. https://eurekamag.com/pdf/003/003552993.pdf

Hayashi T, Takeshita K, Tsuchida N, Kitano K, Kawabata S, Iwanaga S, Ito T. Purification of a novel muscle cell growth factor S-myotrophin from porcine skeletal muscle. Int J Biochem Cell Biol 1998;30(8):897-908. https://www.sciencedirect.com/science/article/pii/S1357272598000521

Best wishes from Germany and all the best for your research,

Martin