Has CAR T-cells been used successfully for solid cancers? What phase are the most clinical trials for solid tumor treatments?

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Focus on water use optimization or water resource optimization which one is effective way toward sustainability?

Water resources are limited and have been significantly reduced by pollution due to urbanization in recent decades. Therefore, water resource optimization only highlights the ways these resources...

27 July 2024 9,303 1 View

How to do Data Farming and Surrogate Model?

Dear Scholars How is it possible to define an algorithm for data augmentation and use a surrogate model? In particular, I want to use data farming to create artificial data instead of real data...

12 June 2024 2,484 4 View

Hi please how can i find quasi- experimental sample size calculator to compute the exact number ?

i need sample size calculator for quasi study design

02 June 2024 9,822 2 View

Hello drs Im asking about new topics in orthodontic?

hello drs can you help me finding new topics in orthodontic for PhD research, i preferred clinical topics specially using CBCT

30 April 2024 9,258 3 View

Is there a criterion for choosing the secondary outcome or the second dependent variable?

In an interventional study, is there a criterion for choosing a secondary outcome or a second dependent variable? Should these two variables in the study of medical sciences and especially...

26 April 2024 9,695 1 View

How long does e.coli survive on filter paper at room temperature?

I have been sent e.coli strains on filter paper and after 10 days I have not received them yet. I am wondering how long would the bacteria survive. Thank you in advance

21 April 2024 881 0 View

Re perform PCR reaction on the same first one for genotyping?

I performed genotyping analysis. Some samples give a result of one SNP but didnt give a result for another SNP. Note, these SNPs are performed at the same plate (same condition). Depending on the...

26 March 2024 7,013 0 View

Is the behavior of carbon steel (e.g., S275) under tension-compression tests symmetric?

Dear colleagues I am organizing tension tests on some existing steel elements (e.g., S275). I will extract the yielding strength and ultimate strength of the existing steel elements. I believe...

13 March 2024 2,035 0 View

How to calibrate temperature on a Peqlab Primus 25?

We have this machine and the temperatures are not correct. Does anyone know how to calibrate it? Thank you in advance

05 March 2024 5,895 2 View

Evaluation of seismic resilience of steel structures?

Question about how and types of methods to optimize steel structures for seismic resistance

29 February 2024 7,569 4 View

Request Python code?

Request Python code from this article : Gender equity of authorship in pulmonary medicine over the past decade. THANKS!

08 August 2024 6,242 2 View

How are iso-frequency contours plotted?

Let's say we have a standard, regular hexagonal honeycomb with a 3-arm primitive unit cell (something like the figure attached; the figure is only representative and not drawn to scale). The...

07 August 2024 1,937 1 View

Is there any way to quantify bacterial and fungal cells in their mixed culture?

I am working in fungal fermentation of soybean meal and there is bacterial growth in them at times. I am trying to quantify fungal cell counts and bacterial cells; but I haven't been able to do at...

07 August 2024 7,535 4 View

Why does everyone use vs code?

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Why activated CAR-Jurkat cell could not kill targets?

Previously when I co-coluture anti-CD19(FMC63) CAR-Jurkat with Raji with E:T=5:1, Jurkat can eliminate Raji in 24h. However, when I test another CAR construct, although I can dectect totally CD69...

06 August 2024 641 2 View

Is an invitation to join the editorial board of Clinical Cardiology Updates a scam?

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06 August 2024 8,981 8 View

How much total RNA concentration to be extracted from sorted plasma cells from bone marrow of C57BL/6 mice for RT-PCR ?

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05 August 2024 8,835 1 View

How can i do multivariate Time Series forecast using MLP, ANFIS and LSTM?

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05 August 2024 2,977 3 View

How to use Density Functional Theory to calculate carrier mobilities of solid system?

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04 August 2024 8,894 1 View

Does long-term culture of murine Monocytes result in macrophage differentiation?

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Daniel Schuette

A recent NEJM review addressing the latest trends in CAR T cell therapy: Article Chimeric Antigen Receptor Therapy

Marialuigina Fruscella

In solid tumor there are not receptors that can be bioengineered.

Cuong Manh Vo

Treatment of CAR-T cells has some limitations in solid tumors when the proliferation rate of CART is very low after injection. Furthermore, CART cells cannot or very limited infiltrate into solid tumor sites.