Has CAR T-cells been used successfully for solid cancers? What phase are the most clinical trials for solid tumor treatments?
Why have they been less used to treat solid cancer?
A recent NEJM review addressing the latest trends in CAR T cell therapy: Article Chimeric Antigen Receptor Therapy
In solid tumor there are not receptors that can be bioengineered.
Treatment of CAR-T cells has some limitations in solid tumors when the proliferation rate of CART is very low after injection. Furthermore, CART cells cannot or very limited infiltrate into solid tumor sites.
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