Most fluors degrade rather quickly for real-time optical measurements, are there any compounds that do not experience this or have minor degradation during hydrolysis?
You may look into core-shell quantum dots or the newer class of rare earth luminescent nano particles in case you do not want to work with Cadmium Selenide particles. they do not photobleach, have excellent optical cross-section and quantum yields and can be excited over a wide range of wavelengths. There are also various surface chemistries available for the tags.