I have a mutant zebrafish strain that likely has hypothryoidism as a result of the mutation. I am basing this on the fact that the adults are dwarfs compared to wild type fish and also do not reproduce. We use T3 in our lab for other developmental purposes but T3 itself is quite toxic, even in small amounts and I do not want to risk losing my fish. I have been reading that Levothyroxine is a routine treatment for hypothyroidism in humans. Also, I have found Levothyroxine on Sigma's website but no papers that show its usage in model organisms. Any advice please?
Levothyroxine has a narrow therapeutic index in humans. This means there is a narrow difference between the minimal effective dose and toxic dose in humans. This window can be so narrow that human patients may experience adverse effects or re-occurrence of disease symptoms even when maintaining the same dose but switching manufacturers of their levothyroxine. Keep this in mind when you're designing your dosing protocol.
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