Hello, Im trying to make phosphopeptide conjugated to poly-Arg for better cell permeability. Im wondering if the positively charged Arg will form stable intra-molecule interaction with negatively charged phosphate, which could abolish the activity of the phosphopeptide? If this is the case, is there any tricks can be applied to minimise this effect such as change the linker length between the CPP and core peptide? Thanks for your help.