Ok, and what have you done sofar?

Alex

This compound has boiling point of 302 C. You cannot even evaporate it in the injector port. It will be tough to by GC. May need to use LC

Dear Alex and Narong,

Thanks for answering my question.

In fact, I have the same thought as Dr Narong about Sandenol's high boiling point. However, I still gave it a try and found no Sandenol detected by GCMSD. Tried searching Sandenol's GCMS chromatogram online as reference, but I couldn't find it.

A colleague of mine speculated that despite Sandenol's high boiling point it still can be detected in GCMS.

So, hope you guys are able to clear my doubt on this.

Thanks. 

It makes no sense. If you inject the liquid sample into an injector port which can heat only as high as 270 C, you cannot change the analyte from liquid phase to gas phase. It would not go thru the column via helium gas and that is why you do not see it in the GC/MS. This is the same way why you smell perfume but not smell the rock because it has different boiling point.   Ask your friend to show the paper of his.

Narong,

Yes it makes sense. The injector does NOT have to reach the boiling point of your compound. Take for example the GCMS analysis of PAH. All the 16 PAH can easily be measured with GCMS. Phenanthrene, by far not the PAH with the highest boiling, (BP ~330°C) can easily be measured with GCMS. 

Looking at the stucture I don't see an immediate problem. The alcohol group shouldn't be big problem with a new column. An older column with active sites could cause a problem. What column did you use? Was you concentration high enough?

Tried looking for publications on PubChem, no luck. And no spectrum in NIST14 database.

Searched for sandal hexanol (synonym for sadenol) on google and found a chromatogram. Drawn structures lookes different than sandenol but very similar (isomer). 

http://phytochemiaactaen.blogspot.nl/2015/11/isobornyl-cyclohexanol-and-you.html

I think you should be able to measure this compound using GCMS with a DB1 or DB5 column.

Alex

http://phytochemiaactaen.blogspot.nl/2015/11/isobornyl-cyclohexanol-and-you.html

Thanks to both Alex and Narong.

Whether an analyte can be vaporized in the injection port depends on the "vapor pressure" of the analyte.  Some analyte despite its high boiling point (low vapor pressure) still can be vaporized but to a lesser extend as compared to those analyte with low boiling point (high vapor pressure).

Sandenol has high boiling point, so I believe most of it will stay in the injection port while a small portion will vaporize and remain in the carrier gas.  But if the concentration of sandenol in the gas phase is not high enough to be detected by the GCMS, increasing the injection volume (or concentration) may be possible. Not recommended though since this might clot the inlet liner or column. 

These are my opinion and please do correct me if i got them all wrong.

Thanks a lot.