Blinatumomab infusion causes high fever which is sometimes hard to control, and I wonder if anybody has used Dantrolene to control high fever even if CK is in the normal range?
We used Dantrolene in the late 80's and early 90's for hight fevers and rigors associated with amphotericin B. We gave it rapid IVpush. That was gradually replaced with demerol. I have not seen dantrolene used snce that time.
Julie, thank you for your reply. Theses days Dantrolene is mostly used in the operating rooms for patients who develop malignant hyperthermia. However, I have been able to control very high fevers associated with Blinatumomab by using Dantrolene.