I have been synthesizing some ILs, and I always purify them by precipitation, either in diethyl or in petroleum ether.
Considering that I can run TLCs and I can see my product going up on the TLC without any degradation pathway, can I run a column chromatography for them? Have you ever done it before?
I am asking that because all the procedures that I find for IL purification are precipitation, distillation, crystallization, techniques using absorbent agents, etc. However, column chromatography seems always the best and practical alternative for me.
Thank you!!!!
If you can run a TLC, you can do column chromatography. There is a direct relationship between the retention on TLC and the elution time on a column if the TLC plate is properly run [1]. A column and TLC plate are both chromatography. The other techniques are maybe more scalable for industrial settings.
[1] Article Let Us Teach Proper Thin Layer Chromatography Technique!
Thank you Jack Silver, indeed I carried out the column and everything went according to the plan. Thank you!!
I forgot to mention but the next reaction step is an ionic exchange, so it does not really matter if the ionic liquid exchanges the anion into the column.
Hi Gabriel,
Check out this paper on IL chromatography and then make sure you reference them when using their technique, it's a very useful methods paper:
https://www.sciencedirect.com/science/article/abs/pii/S0040403912007010
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