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Article Gut Microbiota and Obesity

Article The gut microbiota and its relationship to diet and obesity:...

Article The role of gut microbiota in human obesity: Recent findings...

See links:

Article Gut Microbiota and Obesity

Article The gut microbiota and its relationship to diet and obesity:...

Article The role of gut microbiota in human obesity: Recent findings...

A new study by the Free University of Brussels in Belgium shows a relationship between the number of bacteria in the intestines and the susceptibility to medical complications associated with obesity. Belgian researchers have shown that people with low numbers of bacteria in their intestines are most likely to develop obesity-related complications, such as cardiovascular disease and diabetes, as "intestinal bacterial germination" reduces the number of bacteria.

@ Wesam Salah Ibrahim

The human intestine is colonized by millions of bacteria which form the intestinal flora, known as gut flora. Studies reveal that lean and overweight human may present a difference in the composition of their intestinal flora. Several mechanisms explain the correlation between intestinal flora and obesity. The intestinal flora would increase the energetic extraction of non-digestible polysaccharides. In addition, the lipopolysaccharide from intestinal flora bacteria could trigger a chronic sub-clinical inflammatory process, leading to obesity and diabetes. Another mechanism through which the intestinal flora could lead to obesity would be through the regulation of genes of the host involved in energy storage and expenditure. In the past five years data coming from different sources established causal effects between intestinal microbiota and obesity/insulin resistance, and it is clear that this area will open new avenues of therapeutic to obesity, insulin resistance and DM2.

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Gut microbiota also may contribute for metabolic disturbances observed in obesity by triggering systemic inflammation . Lipopolysaccharides (LPS) from gut microbiota, present in cell membrane of those gram-negative bacteria ...

Gut microbiota also may contribute for metabolic disturbances observed in obesity by triggering systemic inflammation . Lipopolysaccharides (LPS) from gut microbiota, present in cell membrane of those gram-negative bacteria ...

Great thanka dear@Nihada Ahmetovic for your good suggestion of the interested papers.

Great thanka dear@ Djaafar Zemati for your good explanations and nice suggestion of the interested papers.

Great thanka dear@ Arvind singh for your good explanations and nice suggestion of the interested papers.

Obesity and its associated complications like type 2 diabetes (T2D) are reaching epidemic stages. Increased food intake and lack of exercise are two main contributing factors. Recent work has been highlighting an increasingly more important role of gut microbiota in metabolic disorders. It’s well known that gut microbiota plays a major role in the development of food absorption and low grade inflammation, two key processes in obesity and diabetes. This review summarizes key discoveries during the past decade that established the role of gut microbiota in the development of obesity and diabetes. It will look at the role of key metabolites mainly the short chain fatty acids (SCFA) that are produced by gut microbiota and how they impact key metabolic pathways such as insulin signalling, incretin production as well as inflammation. It will further look at the possible ways to harness the beneficial aspects of the gut microbiota to combat these metabolic disorders and reduce their impact

please see the pdf

Article Gut Microbiota and obesity

https://www.researchgate.net/profile/Nirmala_Svsg/post/Gut_microbiota_and_obesity/attachment/5c248906cfe4a764550be303/AS%3A708362740199424%401545898246455/download/4095789.pdf

Very nice review, thanks @ dear Nirmala S.V.S.G

Great thanka dear@ Nihada Ahmetovic , Nirmala S.V.S.G and Arvind Singh for your good explanations and nice suggestions of the interested papers.

This is an interesting article for your question

Adv Nutr. 2016 Nov 15;7(6):1080-1089. doi: 10.3945/an.116.012914. Print 2016 Nov.

Gut Microbiota in Obesity and Undernutrition.

de Clercq NC1, Groen AK2,3, Romijn JA2, Nieuwdorp M2,4,5.

Yes. Possible role exists. Gut microbiota can influence energy extraction from food, lipid metabolism, immune response and endocrine functions and its profile has shown to differs between obese and lean subjects.

Dysbiose & Obesity

You can find what you need in Turnbaugh et al. 2006 study . Nature

Thanks a lot for your valuable discussion Dear @ Meliani Amina, @Muhammad Younas, @Catia Cillonize

The resident bacteria within the GI tract are responsible for a significant portion of our energy intake, allowing us access to energy sources that may have otherwise been indigestible.

Peter J. Turnbaugh et al (2006) reported that the comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes.

Their results indicated that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an ‘obese microbiota’ results in a significantly greater increase in total body fat than colonization with a ‘lean microbiota’.

They identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity

Thanks dear@ Meliani Amina for this interesting paper and great results. May I ask you to send the title of this paper?

Thanks again@Meliani Amina

you're welcome

"An obesity-associated gut microbiome with increased capacity for energy harvest"

• Peter J. Turnbaugh et al (2006),Nature
• dear Wesam , you can search for the 3 imoprtants key words: disbose, eubiose, microbiote and obesity
• good chance for your research

Please accept my cordial regards dear@Meliani Amina , Thanks

Dear Wesam

Thank you very much for your kind message

Best wishes

Composition of gut microbiota is affected by many factors such as diet, disease state, medications as well as host genetics to name a few. As a result, the composition of the gut microbiota is constantly changing affecting the health and well-being of the host such as disease state as well as the use of various medicines such as antibiotics