My greeting for everybody who work on graphene nano particle on animal model , cell line & tissue culture please inform me specially in Iraqi University
What do you mean by graphene nanoparticles?
If you mean nanographene, you can also search for polycyclic aromatic hydrocarbons, at least in large parts of the community those terms are used equivalently:
Article Nanographenes as Active Components of Single-Molecule Electr...
Regarding the interactions with living matter: the smaller PAHs are known to cause cancer due to potential reactions with DNA:
Article Polycyclic aromatic hydrocarbons and PAH-related DNA adducts
Larger PAHs are less reactive and are less toxic due to their reduced solubility, essentially they are soot/dust particles for your body.
Jürgen Weippert i mean graphene and its components such as graphene oxide
that had been used widely in different fields
Well, there is a large variety of graphene species and therefore also a lot of studies. For pure graphene my answer from above stays valid, for graphene oxide it depends what kind of oxides you have: there are epoxides, ethers, ketones, lactones and, if produced by standard proceduressuch as Hummers-Offeman or Staudenmaier, mixtures of those. Their reactiity is different depending on the kind of oxide species you encounter: epoxides are pretty reactive and may also react with enzymes and DNA, see:
https://www.sciencedirect.com/topics/chemistry/epoxide
A part of why PAHs may cause cancer is because they are epoxidized and those epoxides are added to the DNA by a nucleophilic substitution reaction. The other oxides are less reactive and therefore less harmful but I still wouldn't eat them. Essentially graphene (oxides) are a part of soot and you wouldn't ingest that, either.
Jürgen Weippert
Many thanks for this information ,really i searching for graphene oxide whatever the method that been oxidized but you give me important note about their damage for DNA ..........by this method
I will contact with you if you never mind.
best regards
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