I was under the impression that, in general, the higher a drugs affinity to globular plasma proteins the slower it eliminated due to a lower free concentration (hence a lower concentration gradient between the vascular system and other compartments) and that albumin-drug complexes are less membrane permeant than the free drug.
If the above is true, how is penicillin eliminated so quickly given its high affinity to albumin?
Hello,
I think, this article may guide you
Facilitation of penicillin haptenation to serum proteins. J T DiPiro, N F Adkinson, Jr, and R G Hamilton. Antimicrob Agents Chemother. 1993 Jul; 37(7): 1463–1467.
I think that amoxicillin is a highly hydrophilic compound and I think a strong acid too. Given this fact, a large proportion of amoxicillin in blood is ionised. So, the free drug in blood will be eliminated rapidly via the kidneys and the partition between free and protein-bound drug will favor the continual release of the bound drug molecules from albumin.
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